Abstract Background Chemical compounds affecting a bioactivity can usually be classified into several groups, each of which shares a characteristic substructure.We call these substructures "basic active structures" or BASs.The extraction of BASs is challenging when the database of compounds contains a variety of skeletons.Data mining technology, associated with the work of chemists, has enabled the systematic elaboration of BASs.Results This paper presents a BAS knowledge base, BASiC, which currently covers 46 activities Reframing healthy food choices: a content analysis of Australian healthy eating blogs and is available on the Internet.
We use the dopamine agonists D1, D2, and Dauto as examples and illustrate the process of BAS extraction.The resulting BASs were reasonably interpreted after proposing a few template structures.Conclusions The knowledge base is useful for drug design.Proposed BASs and their supporting structures in the knowledge base will facilitate the development of new template structures for other activities, and will be useful in the design of new lead compounds via reasonable interpretations Economic burden of varicella in children 1–12 Years of age in Hungary, 2011–2015 of active structures.